The discrepancy may be due to the following reasons: 1.

Molecular Location: base pairs 111,766,933 to 111,817,532 on chromosome 12 (Homo sapiens Updated Annotation Release 109.20200522, GRCh38.p13) (NCBI)

Inhibition of ALDH2 by disulfirm could further increase the level of ROS, which could be highly cytotoxic in ALDH2-deficient cancer … reported a reduced risk of head and cancer among individuals with ALDH2*2/*2 genotype, likely due to the lower consumption of alcohol among these individuals [].In addition, ALDH2*1/*2 genotype showed gene-environment interaction with the level of alcohol consumption []. The “Asian flush” can disappear for some people later in their lives, especially if they continuously “practice” drinking.

A new study has shown that gene therapy to treat one of the most common hereditary disorders, aldehyde dehydrogenase type 2 (ALDH2) deficiency, may prevent increased risk for esophageal cancer … When you drink alcohol (ethanol or ethyl alcohol), the liver converts it to acetaldehyde. In a meta-analysis of six case-control studies (945 cases and 2917 controls), Boccia et al.

This is mainly because we have yet to see large numbers of deaths primarily caused by acetaldehyde-induced esophageal cancer. ), and 2 to 12 times more likely to develop esophageal cancer compared to people with normal ALDH2*1 [17-25]. Cytogenetic Location: 12q24.12, which is the long (q) arm of chromosome 12 at position 24.12. Alcohol intolerance is usually caused by a genetic metabolic disorder. Understanding ALDH2 deficiency is essential if you are someone who gets a flushed red face after you consume alcohol.

Awareness of Acetaldehyde-Related Cancer. The A allele (Lys504) acts as a dominant negative, since the variant form can suppress the activity of the Glu504 form (G allele) in GA heterozygotes by the formation of heterotetramers. In this study, we show that ALDH2 deficiency exacerbates alcohol-associated HCC development both in patients and mouse models. From the above facts people with Aldh2 deficiency should avoid alcohol in any form. Because of the increased salivary acetaldehyde, people with ALDH2 deficiency are 2 to 8 times more likely to develop head and neck cancers (including oral cancer, pharyngeal cancer, laryngeal cancer, etc. Educating friends, family, and …

This will not only help you drink more comfortably but also help you avoid serious health risks specific to people with this condition. Enzymes (proteins that control the breakdown of foods) are less active or inactive due to the mutation. Some time the entire body gets flushed if the deficiency of Aldh2 is pronounced. ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles. Overall, global awareness of ALDH2 deficiency and its causal relationship with cancer remains relatively low. In this study, we show that ALDH2 deficiency exacerbates alcohol-associated HCC development both in patients and mouse models. Cancer cells may be addictive to certain oncogenic signaling, such as ACE and ROS in ALDH2-deficient cancer cells.

Head and neck cancer. Acetaldehyde is a carcinogen in humans. Following the first study [], which was conducted in the Japanese population, case control studies in Japan and Taiwan have consistently demonstrated a strong link between the risk of esophageal squamous cell carcinoma (Figure 3) and alcohol consumption in low-activity ALDH2 … Aldh2 E487K KI Mice Model Human Deficiency in Alcohol Metabolism. Author information: (1)Laboratory of Liver … Those with ALDH2 Deficiency are at a significantly increased risk of gastric and esophageal cancer.

Results show that the ALDH2 polymorphism is significantly associated with esophageal squamous cell dysplasia. The researchers add that many ALDH2-deficient university students may have their first experiences with heavy drinking while in college.

In addition, the research on ALDH2 deficiency is relatively new. What is ALDH2 deficiency? Therefore, it is particularly important for university health professionals to be aware of the relationship between ALDH2-deficiency, facial flushing, and alcohol-related cancer risk. ALDH2 deficiency resulting from a Glu504Lys substitution (rs671, hereinafter referred to as the A allele) is highly prevalent in East Asian populations. ALDH2 deficiency promotes liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles [40]. Seo W(1), Gao Y(2), He Y(1), Sun J(3), Xu H(3), Feng D(1), Park SH(1), Cho YE(4), Guillot A(1), Ren T(1), Wu R(3), Wang J(3), Kim SJ(1), Hwang S(1), Liangpunsakul S(5), Yang Y(6), Niu J(3), Gao B(7). Alcoholics with an ALDH2 polymorphism have an increased risk of digestive tract cancer development, however, the link between ALDH2 deficiency and hepatocellular carcinoma (HCC) development has not been well established. ALDH2 Deficiency has serious health implications and should not be taken lightly.

Lay summary. Evidence That ALDH2 Deficiency Increases the Risk of Alcohol-Related Squamous Cell Esophageal Cancer.

ALDH2 catalyzes ACE metabolism and plays important roles in the pathogenesis of cardiovascular diseases, diabetes, neurodegenerative diseases, and cancer . As a result, ALDH2-deficient patients can then be counseled to reduce alcohol consumption, and high-risk patients can be assessed for endoscopic cancer …